Spyre Therapeutics, Inc. Commo | SYRE | Nasdaq | Latest report: February 27, 2026
Spyre Therapeutics, Inc. Commo (SYRE) reported short interest of 9,985,198 shares for the settlement date of February 27, 2026. The prior report showed 9,862,924 shares. That was a change of 122.3K shares, while the latest days-to-cover reading came in at 12.42 using reported average daily volume of 803.7K.
The historical data currently tracked for SYRE includes 52 reported entries from November 30, 2023 to February 27, 2026. During that span, reported short interest ranged between 206.5K and 14.1M shares.
Extreme edge-case readings may reflect unusually low reported average volume.
| Settlement Date | Short Interest | Prior Short Interest | Change Shares | Change % | Average Daily Volume | Days to Cover |
|---|---|---|---|---|---|---|
| February 27, 2026 | 9,985,198 | 9,862,924 | 122.3K | +1.2% | 803.7K | 12.42 |
| February 13, 2026 | 9,862,924 | 9,980,496 | -117.6K | -1.2% | 663.2K | 14.87 |
| January 30, 2026 | 9,980,496 | 10,069,741 | -89.2K | -0.9% | 492.0K | 20.29 |
| January 15, 2026 | 10,069,741 | 11,636,998 | -1.6M | -13.5% | 724.8K | 13.89 |
| December 31, 2025 | 11,636,998 | 11,818,159 | -181.2K | -1.5% | 827.6K | 14.06 |
| December 15, 2025 | 11,818,159 | 11,157,711 | 660.4K | +5.9% | 852.2K | 13.87 |
| November 28, 2025 | 11,157,711 | 12,464,842 | -1.3M | -10.5% | 611.0K | 18.26 |
| November 14, 2025 | 12,464,842 | 12,407,305 | 57.5K | +0.5% | 618.5K | 20.15 |
| October 31, 2025 | 12,407,305 | 13,390,470 | -983.2K | -7.3% | 1.0M | 11.89 |
| October 15, 2025 | 13,390,470 | 14,459,688 | -1.1M | -7.4% | 1.5M | 9.19 |
| September 15, 2025 | 13,780,763 | 14,087,087 | -306.3K | -2.2% | 483.0K | 28.53 |
| August 29, 2025 | 14,087,087 | 13,187,699 | 899.4K | +6.8% | 480.0K | 29.35 |
| August 15, 2025 | 13,187,699 | 12,879,446 | 308.3K | +2.4% | 432.4K | 30.5 |
| July 31, 2025 | 12,879,446 | 13,602,876 | -723.4K | -5.3% | 551.7K | 23.35 |
| July 15, 2025 | 13,602,876 | 13,486,500 | 116.4K | +0.9% | 588.2K | 23.13 |
| June 30, 2025 | 13,486,500 | 12,592,074 | 894.4K | +7.1% | 795.6K | 16.95 |
| June 13, 2025 | 12,592,074 | 12,090,208 | 501.9K | +4.2% | 461.5K | 27.28 |
| May 30, 2025 | 12,090,208 | 12,296,733 | -206.5K | -1.7% | 364.0K | 33.21 |
| May 15, 2025 | 12,296,733 | 12,553,112 | -256.4K | -2.0% | 592.7K | 20.75 |
| April 30, 2025 | 12,553,112 | 11,749,883 | 803.2K | +6.8% | 587.1K | 21.38 |
| April 15, 2025 | 11,749,883 | 11,358,696 | 391.2K | +3.4% | 1.0M | 11.52 |
| March 31, 2025 | 11,358,696 | 10,767,640 | 591.1K | +5.5% | 645.1K | 17.61 |
| February 28, 2025 | 10,022,703 | 9,923,952 | 98.8K | +1.0% | 623.3K | 16.08 |
| February 14, 2025 | 9,923,952 | 10,235,934 | -312.0K | -3.0% | 581.6K | 17.06 |
| January 31, 2025 | 10,235,934 | 10,003,304 | 232.6K | +2.3% | 611.0K | 16.75 |
| January 15, 2025 | 10,003,304 | 9,940,874 | 62.4K | +0.6% | 554.1K | 18.05 |
| December 31, 2024 | 9,940,874 | 9,620,365 | 320.5K | +3.3% | 499.9K | 19.88 |
| December 13, 2024 | 9,620,365 | 8,859,758 | 760.6K | +8.6% | 488.9K | 19.68 |
| November 29, 2024 | 8,859,758 | 8,040,536 | 819.2K | +10.2% | 925.9K | 9.57 |
| November 15, 2024 | 8,040,536 | 8,250,593 | -210.1K | -2.5% | 542.1K | 14.83 |
| October 31, 2024 | 8,250,593 | 8,413,483 | -162.9K | -1.9% | 359.7K | 22.94 |
| October 15, 2024 | 8,413,483 | 8,644,070 | -230.6K | -2.7% | 381.6K | 22.05 |
| September 30, 2024 | 8,644,070 | 8,724,826 | -80.8K | -0.9% | 828.7K | 10.43 |
| September 13, 2024 | 8,724,826 | 8,462,948 | 261.9K | +3.1% | 412.2K | 21.16 |
| August 30, 2024 | 8,462,948 | 8,042,707 | 420.2K | +5.2% | 422.7K | 20.02 |
| August 15, 2024 | 8,042,707 | 7,811,572 | 231.1K | +3.0% | 387.0K | 20.78 |
| July 31, 2024 | 7,811,572 | 9,053,899 | -1.2M | -13.7% | 440.1K | 17.75 |
| July 15, 2024 | 9,053,899 | 7,790,902 | 1.3M | +16.2% | 610.8K | 14.82 |
| June 28, 2024 | 7,790,902 | 4,842,295 | 2.9M | +60.9% | 1.8M | 4.3 |
| June 14, 2024 | 4,842,295 | 4,575,641 | 266.7K | +5.8% | 455.3K | 10.63 |
| May 31, 2024 | 4,575,641 | 4,517,727 | 57.9K | +1.3% | 295.4K | 15.49 |
| May 15, 2024 | 4,517,727 | 4,381,088 | 136.6K | +3.1% | 311.0K | 14.53 |
| April 30, 2024 | 4,381,088 | 3,555,205 | 825.9K | +23.2% | 313.1K | 13.99 |
| April 15, 2024 | 3,555,205 | 3,012,956 | 542.2K | +18.0% | 322.8K | 11.01 |
| March 28, 2024 | 3,012,956 | 2,878,707 | 134.2K | +4.7% | 523.8K | 5.75 |
| March 15, 2024 | 2,878,707 | 2,150,882 | 727.8K | +33.8% | 852.5K | 3.38 |
| February 29, 2024 | 2,150,882 | 1,590,726 | 560.2K | +35.2% | 627.5K | 3.43 |
| February 15, 2024 | 1,590,726 | 710,964 | 879.8K | +123.7% | 343.1K | 4.64 |
| January 31, 2024 | 710,964 | 527,386 | 183.6K | +34.8% | 287.8K | 2.47 |
| December 29, 2023 | 372,854 | 215,128 | 157.7K | +73.3% | 102.6K | 3.63 |
| December 15, 2023 | 215,128 | 206,473 | 8.7K | +4.2% | 189.7K | 1.13 |
| November 30, 2023 | 206,473 | 139,688 | 66.8K | +47.8% | 93.1K | 2.22 |